Article 11119

Title of the article

COMPARISON OF THE EFFECT OF NEW CONNECTIONS FROM THE GROUP
3-HYDROXYPYRIDINE AND MEXIDOL ON THE EXCHANGE PROCESS IN DIABETES-INDUCED DIABETES 

Authors

Ulanova Tat'yana Vyacheslavovna, Candidate of medical sciences, associate professor, sub-department of normal and pathological physiology with a course of hygiene, National Research Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: tatyana_304@mail.ru
Tuzhilkina Ekaterina Alekseevna, Student, National Research Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: tuzhilkinacatherine@yandex.ru
Ruseykin Nikolay Sergeevich, Candidate of medical sciences, professor, head of the sub-department of normal and pathological physiology with a course of hygiene, National Research Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: nsruseikin@yandex.ru 

Index UDK

615:616.379-008.64 

DOI

10.21685/2072-3032-2019-1-11 

Abstract

Background. WHO experts evaluate type diabetes mellitus as a noncommunicable disease epidemic. Clinical signs of complications are already being identified in many patients who seek help from medical institutions. Timely administration of insulin therapy and oral hypoglycemic agents helps to improve the quality of life, but the frequency of complications of this disease does not decrease. In this regard, the search for new medicinal compounds continues, corrective pathogenetic disorders in diabetes mellitus, able to significantly reduce the frequency of complications and, consequently, reduce the risk of disability and mortality.
Materials and methods. For the study used white rats of male and female sexually mature, weighing 185-230g, kept in the vivarium room in standard conditions; who have been artificially caused by diabetes. Used: alloxan 135 mg. per kilogram of weight (this substance destroys the pancreatic β-cells and leads to a sharp decrease in insulin production), fumarate 3-hydroxypyridine (3-GP), nicotinate 3-GP and mexidol were chosen as means of correction.
Results. Nicotinate 3-GP and Fumarat 3-GP reduces the blood glucose level against the background of induced diabetes. Fumarate 3-GP enhances and prolongs the effect of insulin, and also reduces the level of adrenal glycemia.
Conclusions. As a result of the study, the hypoglycemic effect of fumarate 3-GP and nicotinate 3-GP, as well as the insulin potentiation and antiadrenergic effect of fumarate 3-GP on experimental rats, which was accompanied by the absence of mortality, was proved. 

Key words

diabetes, fumarate 3-GP, nicotinate 3-GP 

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References

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Дата создания: 26.06.2019 09:20
Дата обновления: 26.06.2019 13:59